9/1/2023 0 Comments Antidote paracetamol toxicity![]() This refers to a delay between the time of overdose and presentation to medical care. If the time of ingestion is unknown patients should be treated as a ‘staggered overdose’. However, if paracetamol above the recommended daily dose (4g/24 hours in adults) is ingested for the two preceding days or more, the risk increases.Īll patients that have taken a staggered overdose should be referred to hospital for assessment. ![]() Doses consistently < 75 mg/kg in any 24 hour period are unlikely to be toxic. Rarely, toxicity may occur for ingestions between 75-150 mg/kg. Serious toxicity may occur in patients who have ingested > 150 mg/kg in any 24 hour period. This refers to excessive ingestion of paracetamol over a period longer than one hour, usually in the context of self-harm. ![]() Serious toxicity is unlikely if a patient has ingested 75 mg/kg, are symptomatic, or need urgent psychiatric assessment (if taken in context of self-harm), hospital admission is warranted. This refers to the ingestion of a potentially toxic dose of paracetamol within one hour or less. ![]() It is essential to understand and characterise the type of paracetamol ingestion as it determines management. ![]()
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